תרופה נוספת אושרה למניעת מחלות לב בחולי סוכרת

חולי סוכרת סובלים מעליה של 70% בסיכון לתמותה ממחלות כלי דם של הלב. תרופות שמפחיתות את הסיכון לתמותה ממחלות לב משמעותיות מאוד לטיפול בחולים אלה.

בתאריך ה 22 לדצמבר 2016 דווחתי בפוסט שפרסמתי לפני כחצי שנה כי ה FDA אישר תרופה בשם Jardiance למניעת מחלות לב בחולי סוכרת (גוללו מטה לעיון בפוסט). השבוע נפגשה שוב הוועדה לתרופות אנדוקריניות ומטבוליות של מינהל המזון והתרופות האמריקאי (FDA) ואישרה ברוב מוחץ את השימוש בתרופה נוספת, Victoza, (מוכרת גם בשם Liraglutide) לאותה מטרה. החלטת הוועדה נסמכת על מחקר שפורסם לפני כשנה ובדק את השפעת הטיפול על מחלות לב. המחקר מצא כי Victoza מצמצת את התמותה ממחלות לב ב 13%.

Victoza היא תרופה המוזרקת תת עורית, מעודדת את הפרשת האינסולין על ידי תאי הלבלב ואושרה לטיפול בחולי סוכרת בתחילת 2010. תופעות הלואי השכיחות של התרופה כוללות תגובה מקומית בעור, בחילות ולעיתים שלשולים שעל פי רוב חולפות עם שינויים במינון.

כדאי לשים לב כי Jardiance ו Victoza משפרות את איזון הסוכרת במנגנונים שונים לחלוטין (שלא כמו Victoza , התרופה Jardiance מגדילה את הפרשת הגלוקוז בשתן) ושתיהן ידועות כטיפול יעיל גם לעודף משקל. יהא זה מעניין לבחון את השפעתו של טיפול משולב בשתי התרופות על משקל הגוף ושיעור מחלות הלב בחולי סוכרת.

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