טיפול חדשני באוסטאופורוזיס מצמצם ב 73% הופעת שברים בחוליות עמוד השדרה

תהליך האוסטאופורוזיס אחראי למרבית השברים בעצמות של נשים לאחר גיל הבלות. למרבה הצער, יכולתם של טיפולים קיימים למנוע את הופעתם של השברים מוגבלת למדי. במהלך החיים עצמות משנות את המבנה שלהן בהתמדה וזאת בזכות פעילות משולבת של תאים הממיסים את העצם מחד ותאים אחרים המיצרים עצם מאידך. מטופלים עם אוסטאופורוזיס סובלים מהפרה של האיזון בין תהליך ההמסה ותהליך הייצור מה שמחליש אותן ומוביל בסופו של דבר להופעת השברים.

מחקר שבדק את השפעתם של נוגדנים המפעילים את התאים יוצרי העצם מחד ומדכאים את פעילותם של תאים הממיסים את העצם מאידך (הנוגדנים מיוצרים על ידי Amgen/UCB Pharma תחת השם רומוסוצומב), מצא כי טיפול של שנה בנשים בגיל הבלות עם אוסטאופורוזיס חמורה גרם לירידה של 73% בהופעתם של שברים בחוליות עמוד השדרה. יתירה מזו, השפעת הנוגדנים היתה מהירה מאוד. כעבור 6 חודשי טיפול נצפו שני שברים בלבד (!) בנשים שקבלו את  הנוגדנים.

ביולי השנה הוגש הטיפול לאישור הרשות האמריקאית לתרופות ומזון (FDA). במידה ויאושר, רומוסוצומב צפוי לחולל שינוי מהותי בטיפול בחולים עם אוסטאופורוזיס מתקדם.

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