תרופה חדשה הביאה לשיפור במצב חולי אלצהיימר ולסילוק אמילואיד-בטא ממוחם

 מחלת אלצהיימר מתאפיינת בהצטברותו של החלבון אמילואיד-בטא ברקמת המוח. להצטברות יש השפעה רעילה על תאי המוח ומובילה למות התאים ולהתדרדרות בתפקוד המוחי בחולים במחלה. בישראל יש כ-70 אלף אנשים הלוקים במחלת אלצהיימר וההערכה היא שתוך 15 שנה, עם העלייה בתוחלת החיים, יגדל מספרם ל-120 אלף. מרבית החולים מתים לאחר 15-10 שנה מפרוץ ומאבחון המחלה.

ניסוי בתרופה חדשה, (נוגדן בשם aducanumab הניתן בהזרקה ופותח על ידי חברת Biogen האמריקאית) הראה כי היא עשויה לסייע משמעותית לחולי אלצהיימר בשלבים המוקדמים ביותר של המחלה; כך דווח במאמר שפורסם בימים האחרונים בעיתון היוקרתי Nature.

המחקר כלל 165 חולי אלצהיימר עם תסמינים קלים של המחלה ותוכנן במקור להערכת בטיחות השימוש בתרופה, ולא נועד לברר אם התרופה תגרום לשיפור במצב החולים. אף על פי כן, עיבוד נתוני המחקר העלה את האפשרות שהטיפול עזר להאט את קצב ההתדרדרות בתפקוד המנטלי של חולי האלצהיימר שקבלו את התרופה. הזרקת הנוגדן במשך 12 חודשים הביאה לסילוק גושי חלבון אמילואיד-בטא שהצטברו בתאי המוח וגורם, על פי התיאוריה המובילה נכון להיום, להופעת המחלה.

בניסוי התברר, כי משתתפים שקיבלו את המינון הגבוה ביותר של התרופה הציגו את השיפור הרב ביותר בתפקוד המוחי ושכבת האמילואיד-בטא הצטמקה במוחם בשיעור הגבוה ביותר כפי שהוברר בסריקות מוח שעברו. מצב המטופלים בתרופה לא הורע בששה החודשים שלאחר מתן הטיפול.

Screen Shot 2016-09-02 at 11.32.25 PM

בתמונה: השפעת טיפול במינונים עולים של התרופה במשך שנה על תכולת אמילואיד-בטא במוח המטופלים

מאחר ורק קבוצה קטנה מאוד של חולי אלצהיימר השתתפה בניסוי יהיה צורך לאשר את הממצאים ולבססם בניסויים רחבי היקף.

פרופ’ ג'ון הארדי, נוירולוג מיוניברסיטי קולג' בלונדון (UCL), החוקר שהציע את רעיון הצטברות האימילואיד כגורם להופעת אלצהיימר, אמר כי אמנם הממצאים מעניינים מאוד אבל בשל העובדה שבניסוי השתתפו מספר מצומצם של חולים – מוקדם מכדי להסיק מסקנות.

 

1,416 thoughts on “תרופה חדשה הביאה לשיפור במצב חולי אלצהיימר ולסילוק אמילואיד-בטא ממוחם

  1. We're a group of volunteers and starting a new scheme in our community.

    Your site offered us with valuable information to work
    on. You have done an impressive job and our entire community will be grateful
    to you.

  2. Hey There. I found your blog using msn. This is an extremely well written article.
    I'll be sure to bookmark it and return to read more of your useful information. Thanks for the post.
    I'll certainly return.

  3. First off I want to say fantastic blog! I had a quick question that I'd
    like to ask if you do not mind. I was curious to know how you center
    yourself and clear your mind prior to writing.
    I have had trouble clearing my thoughts in getting my thoughts out.
    I do take pleasure in writing but it just seems like the first 10 to 15 minutes
    are usually wasted simply just trying to figure out how to begin. Any ideas or hints?
    Cheers!

  4. I needed to thank you for this great read!! I definitely loved every bit of it.
    I've got you book-marked to look at new stuff you post… games
    ps4 allenferguson games ps4

  5. Usually I do not read article on blogs, but I wish to say that this write-up
    very pressured me to try and do it! Your writing taste has been amazed me.
    Thanks, very great post. games ps4 185413490784 games ps4

  6. It is appropriate time to make some plans for the future
    and it is time to be happy. I have read this post and
    if I could I want to suggest you some interesting things or tips.
    Maybe you can write next articles referring to this article.
    I desire to read even more things about it!

  7. My programmer is trying to convince me to move to
    .net from PHP. I have always disliked the idea because of the expenses.

    But he's tryiong none the less. I've been using WordPress on a number of
    websites for about a year and am anxious about switching to another
    platform. I have heard excellent things about blogengine.net.
    Is there a way I can import all my wordpress content into it?

    Any kind of help would be really appreciated!

  8. Thanks a lot for sharing this with all of us you actually realize
    what you're speaking about! Bookmarked. Kindly also visit my
    website =). We could have a link trade contract between us

  9. I am really impressed along with your writing abilities as smartly
    as with the format for your blog. Is this a paid
    topic or did you customize it yourself? Either way
    stay up the excellent high quality writing, it's rare
    to look a nice weblog like this one these days.. 0mniartist
    asmr

  10. We're a group of volunteers and starting a new scheme in our community.

    Your website provided us with valuable information to work on. You've done a formidable job and our
    whole community will be thankful to you. 0mniartist asmr

  11. An impressive share! I have just forwarded this onto a co-worker who was
    doing a little homework on this. And he actually bought me lunch due to
    the fact that I discovered it for him… lol.
    So let me reword this…. Thank YOU for the meal!!
    But yeah, thanks for spending some time to discuss this
    issue here on your blog.

  12. I know this if off topic but I'm looking into starting my own blog and was
    curious what all is needed to get set up? I'm assuming
    having a blog like yours would cost a pretty penny? I'm not very internet savvy so
    I'm not 100% certain. Any recommendations or advice would be greatly appreciated.
    Thank you

  13. Hello, i think that i saw you visited my site so i came to go back the choose?.I am trying to find issues to enhance my site!I suppose its adequate to
    make use of a few of your ideas!!

  14. Great post. I was checking constantly this
    blog and I'm impressed! Extremely helpful information specially the last part :
    ) I care for such information a lot. I was looking for this particular info
    for a long time. Thank you and best of luck.

  15. Please let me know if you're looking for a article writer for your weblog.
    You have some really good posts and I feel I would be a good asset.
    If you ever want to take some of the load off, I'd love to write some articles for your blog in exchange for a link back to mine.

    Please shoot me an e-mail if interested. Many thanks!

  16. Hc pigment Control Leke Kremi

    HC Pigment-Control'ün cilt lekelerine karşı hızlı ve güçlü
    etkisi, Kuzey Kanada Bozkırları'na özgü bir tarla bitkisi olan Rumeks'ten (Tyrostat™),
    tabiatın yeniden canlandırma mucizesi olan Yeniden Diriliş Bitkisi'ne kadar birçok doğal ve saf aktif bileşene dayalıdır.
    Tüm bu aktif bileşenlerin, lekeler ve cilt yaşlanması üzerindeki etkileri in-vivo testler ve klinik laboratuvar çalışmalarıyla kanıtlanmıştır.

    Tüm cilt tiplerinde, leke problemlerini giderme ve önlemede, cilt tonu eşitsizliğinde, cilt
    aydınlatmasında, nem ihtiyacı olan ciltlerde güvenle kullanılabilir.

    LEKE KREMİ için hemen sitemizi ziyaret et

  17. hello!,I love your writing very much! percentage we keep in touch extra about
    your article on AOL? I require an expert in this house to solve my
    problem. May be that is you! Having a look forward to peer you.

  18. When I originally left a comment I seem to have clicked on the -Notify me when new comments are added- checkbox and now each time
    a comment is added I recieve 4 emails with the exact same comment.
    There has to be an easy method you can remove me from that service?
    Cheers!

  19. Have you ever considered writing an ebook or guest authoring
    on other websites? I have a blog based on the same ideas you discuss and would really like to have
    you share some stories/information. I know my viewers would appreciate your work.
    If you are even remotely interested, feel free
    to send me an e-mail.

  20. It is the best time to make some plans for the longer term and it's time
    to be happy. I've read this publish and if I could I desire to recommend you some fascinating
    things or tips. Perhaps you could write subsequent articles relating to this article.
    I wish to read more things about it!

  21. Greetings from Los angeles! I'm bored to tears at work so I decided to browse your site on my iphone during lunch break.
    I really like the information you provide here and can't wait to take a look when I get home.

    I'm amazed at how fast your blog loaded on my cell phone ..
    I'm not even using WIFI, just 3G .. Anyways, wonderful site!

  22. Attractive section of content. I just stumbled upon your
    web site and in accession capital to assert that I acquire in fact enjoyed account
    your blog posts. Anyway I will be subscribing to your feeds and even I achievement you
    access consistently quickly.

  23. You actually make it seem so easy with your presentation but I find this topic to be really something which I think
    I would never understand. It seems too complex and extremely broad for me.
    I am looking forward for your next post, I'll try to get the hang of it!

  24. Etkileşimi Arttırmak İçin Takipçi ve Beğeni Satın Almalısınız

    Özellikle yeni açılan sosyal medya hesaplarının en büyük sorunları arasında takipçi sayısının düşüklüğü ve paylaşımlarda
    etkileşim olmamasıdır. Beğeni ve yorumların gelmesi sosyal medya hesaplarının gelişimine katkı sağlamaktadır.

    Özellikle çok takipçisi bulunan ve paylaşımları beğenilerek yorum yapılan hesaplar ilgi çekmektedir.
    Takipçi Satın Al işlemleri sayesinde hızlı bir etkileşim sağlanabilmektedir.
    Ancak tüm hizmetlerde olduğu gibi bu hizmetlerinde farklı seçenekleri bulunmaktadır.

    https://rebrand.ly/takipci-satin-al

  25. Thanks a lot for sharing this with all of us you really
    realize what you’re talking about! Bookmarked.
    Please additionally seek advice from my website =).
    We may have a hyperlink alternate arrangement between us

    click here=휴게텔

  26. I've been exploring for a little for any high quality articles or weblog posts on this kind of area .
    Exploring in Yahoo I at last stumbled upon this site. Studying this info So i'm satisfied to express that I've an incredibly just right uncanny feeling I found out exactly what I needed.

    I so much certainly will make sure to do not forget this
    website and give it a look on a relentless basis. http://droga5.net/

  27. Excellent post. I was checking continuously this blog and I'm impressed!
    Very helpful info specifically the last part :
    ) I handle such info a lot. I used to be looking for this certain info
    for a long time. Thank you and good luck.

  28. Howdy this is kind of of off topic but I was wanting to know
    if blogs use WYSIWYG editors or if you have to manually code
    with HTML. I'm starting a blog soon but have no
    coding knowledge so I wanted to get guidance from someone with
    experience. Any help would be enormously appreciated!

  29. I absolutely love your blog.. Excellent colors & theme. Did you make
    this website yourself? Please reply back as I'm attempting to create my own site and would like to find out where you got this from or what
    the theme is named. Cheers!

  30. Does your website have a contact page? I'm having a
    tough time locating it but, I'd like to shoot you an email.

    I've got some creative ideas for your blog
    you might be interested in hearing. Either way,
    great site and I look forward to seeing it expand over time.

  31. Excellent weblog right here! Also your website quite
    a bit up very fast! What host are you the use of? Can I am
    getting your affiliate link for your host? I desire
    my site loaded up as quickly as yours lol

  32. Yesterday, while I was at work, my sister stole
    my iPad and tested to see if it can survive a 30 foot drop, just so
    she can be a youtube sensation. My iPad is now broken and she has 83 views.

    I know this is entirely off topic but I had to share it with someone!

  33. It is appropriate time to make some plans for the future and it is time
    to be happy. I have learn this submit and if I may just I desire to suggest you some fascinating
    issues or tips. Maybe you can write next articles regarding this article.
    I wish to read more issues about it!

  34. You can certainly see your enthusiasm within the work you write.
    The arena hopes for even more passionate writers such as you who are not afraid to mention how they believe.
    All the time go after your heart.

  35. Everything posted made a ton of sense. But, think about this, suppose you were to write
    a awesome title? I ain't suggesting your content is not solid., but what if you added
    a title that makes people desire more? I mean תרופה חדשה הביאה לשיפור במצב חולי אלצהיימר ולסילוק אמילואיד-בטא ממוחם – פרופ'
    אפרים סחייק Ephraim Sehayek M.D is kinda boring.

    You ought to peek at Yahoo's front page and note how they
    create article headlines to grab viewers to open the links.
    You might add a video or a related picture or two to get
    people interested about what you've got to say. Just my opinion, it might bring your blog
    a little bit more interesting.

  36. Aw, this was an incredibly nice post. Finding the time and actual effort to create a top notch article… but what can I
    say… I procrastinate a whole lot and don't manage to get anything done.

  37. When I originally commented I seem to have clicked on the
    -Notify me when new comments are added- checkbox and now every time a comment is added I receive four emails with the exact same
    comment. Perhaps there is an easy method you can remove me from that
    service? Thanks!

  38. Hello! Do you know if they make any plugins to assist with SEO?
    I'm trying to get my blog to rank for some targeted keywords but I'm not seeing very good gains.
    If you know of any please share. Kudos!

  39. Aw, this was a very nice post. In idea I want to put in writing like this additionally – taking time and actual effort to make an excellent article… however what can I say… I procrastinate alot and on no account appear to get one thing done.

  40. Thank you so much for giving everyone an exceptionally spectacular possiblity to read from this web site. It can be very amazing and also packed with a great time for me personally and my office friends to visit the blog at minimum three times in a week to see the fresh things you will have. Not to mention, I am also actually satisfied concerning the awesome tactics served by you. Certain 1 points in this posting are absolutely the most impressive we have all ever had.

  41. Definitely believe that which you stated. Your favorite justification seemed to be at the net the simplest thing to remember of. I say to you, I definitely get annoyed while other folks consider worries that they plainly do not understand about. You managed to hit the nail upon the top and outlined out the entire thing without having side-effects , other folks can take a signal. Will likely be back to get more. Thanks

  42. You really make it appear so easy together with your presentation however I in finding this matter to be really something which I believe I might by no means understand. It kind of feels too complex and extremely broad for me. I'm taking a look forward to your next publish, I’ll attempt to get the hang of it!

  43. I like the helpful information you provide in your articles. I’ll bookmark your blog and check again here frequently. I'm quite sure I will learn many new stuff right here! Good luck for the next!

  44. פינגבאק: viagra buy greece
  45. פינגבאק: cialis alternative