התראת בטיחות של ה- FDA לגבי טיפול באנטיביוטיקות מקבוצת הפלואורוקווינולונים

מנהל המזון והתרופות האמריקאי (FDA) פרסם לאחרונה אזהרת שימוש בתרופות אנטיביוטיות ממשפחת הפלואורוקווינולונים (Fluoroquinolones) לטיפול בזיהומים חיידקיים שאינם חמורים.

תרופות אנטיביוטיות ממשפחת הפלואורוקווינולונים המאושרות לשימוש בישראל כוללות את התרופות הבאות: לבופלוקסצין (Levofloxacin – Levo, Tavanic), ציפרופלוקסצין (Ciprofloxacin – Cifran, Ciprodex, Ciprogis), מוקסיפלוקסצין (Moxifloxacin – Megaxin, Vigamox) ואופלוקסצין (Ofloxacin – Oflodex, Oflox, Tarivid).

תרופות אנטיביוטיות אלה נועדו במקור לטיפול בזיהומים חיידקיים חמורים. עם זאת, סקירת בטיחות מטעם ה- FDA מצאה כי שימוש של פלואורוקווינולונים קשור לתופעות לוואי שכוללות מעורבות של גידים (דלקות וקרעים בגידים), שרירים, מפרקים, עצבים (פגיעה במערכת העצבים ההיקפית) ומערכת העצבים המרכזית. תגובות אלו יכולות להתפתח שעות עד שבועות לאחר התחלת הטיפול והן עשויות להיות בלתי הפיכות!

במרבית המקרים של דלקת חיידקית חריפה בגתות האף (סינוסיטיס), החמרה בדלקת סימפונות כרונית (ברונכיטיס כרונית) ובמצבים של דלקת חיידקית ללא סיבוכים בדרכי השתן, הסיכון בטיפול עולה על יתרונות השימוש בפלואורוקווינולונים. לכן, ה- FDA החליט כי השימוש בפלואורוקווינולונים יינתן רק במטופלים בהם אין אפשרות טיפול אחרת!! לעומת זאת, במקרים של זיהומים חיידקים מסכני חיים (כמו למשל דלקת ריאות חידקית ובמקרים נדירים של אנתרקס ודבר, plague), יתרון השימוש בפלואורוקווינולונים עולה על הסיכון, ולכן במצבים אלה יש הצדקה לטיפול באנטיביוטיקות הללו.

מסקנה: אם אתם לוקים בסינוסיטיס, החמרה של ברונכיטיס כרונית או דלקת בדרכי השתן (ללא סיבוכים!) שימו לב איזו אנטיביוטיקה רושם לכם הרופא. במידה ונרשמה לכם אחת מהתרופות בקבוצת הפלואורוקווינולונים בידקו עם הרופא אם הטיפול מוצדק לאור הסיכון הרצוף לשימוש בקבוצת אנטיביוטיקה זו. 

להלן הקישורית להאזהרה: http://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm513183.htm?source=govdelivery&utm_medium=email&utm_source=govdelivery

 

 

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