טיפול בכולכיצין עשוי לצמצם הופעת מחלות לב ואוטמים מוחיים

חומצה אורית (uric acid) היא תוצר הפירוק של החומר הגנטי בתאינו (DNA) וכלולה בבדיקות מעבדה שגרתיות אותן אנו מבצעים מידי שנה. רמות מוגברות של חומצה אורית בדם מהוות סמן להתפתחות סוכרת, יתר לחץ דם, רמות שומנים מופרעות בדם (כולם גורמי סיכון ידועים למחלות לב). בחלק מאנשים הסובלים מרמות חומצה אורית מוגברת מופיעה שקיעה של החומצה במפרקים וליצירת גבישים בתוך המפרק. הגבישים גורמים לנדידת תאי דם לבנים לתוך המפרק ולדלקת במפרקים (המפרק שבין הבוהן לבין כף הרגל נפגע בשכיחות הגבוהה ביותר). דלקת מפרקים זו נקראת גאוט בלעז או שיגדון בעברית.

הטיפול בשיגדון כולל תרופה בשם כולכיצין, שמשבשת את נדידת התאים הלבנים לתוך המפרקים ובכך מונעת את התהליך הדלקתי. מחקרים ראשוניים רמזו כי כולכיצין עשויה לטפל לא רק בדלקת השיגדון אלא גם בדלקת בכלי הדם הגורמת לטרשת עורקים ובכך לצמצם את הסיכון להתפתחות מחלות לב ואוטם מוחי. עבודת מחקר שפורסמה לאחרונה בקרב חולי שיגדון תומכת באפשרות הזו. השוואה בין כ 500 חולי שיגדון שטופלו בקולכיצין לכ 500 חולים שטופלו בתרופות אחרות הראתה שטיפול בכולכיצין מצמם את הופעתם של אוטם שריר הלב ואוטם מוחי בכ 50% ואת התמותה מכל הסיבות יחדיו בכ 75% !

נותר לראות אם בעתיד כולכיצין תצטרף לאספירין ולסטטינים כתרופה לאלה מאיתנו שמציגים סיכון גבוה להתפתחות מחלות לב. השארו עמנו  Stay tuned

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