רמת כולסטרול בדם קשורה להתפתחות מחלת הסוכרת

מחקרים רבים מעידים כי הטיפול בסטטינים, תרופות המצמצמות את רמות הכולסטרול בדם, מעלות את הסיכון להתפתחות מחלת הסוכרת. כעת מתווסף מידע נוסף שתומך בקשר שבין רמות הכולסטרול בדם והתפתחות סוכרת (ראה קישורית מטה). חוקרים בארצות הברית בדקו את הקשר בין סמנים גנטיים לרמות כולסטרול גבוהות בדם לבין התפתחות מחלת הסוכרת. החוקרים עקבו אחר 6,011 אנשים שאינם מטופלים בסטטינים ואינם סובלים ממחלת לב וכלי דם ובדקו את הקשר שבין הסמנים הגנטיים לבין התפתחות סוכרת במשך כ 4.5 שנים. ראשית, הסמנים הגנטיים אכן נבאו את רמת הכולסטרול (מה שחזק את אמינותם של סמנים אלה בחיזוי רמות הכולסטרול). והעיקר, אנשים עם סמנים גנטיים לרמות כולסטרול גבוהות הציגו עמידות להתפחות מחלת הסוכרת לעומת אנשים עם סמנים גנטיים לרמות כולסטרול נמוכות. כיצד רמות כולסטרול גבוהות מגנות עלינו מפני מחלת הסוכרת? על מנת לענות על השאלה הזו יש צורך במחקרים נוספים שיזהו את המנגנונים. לעת עתה, ההמלצה שלי היא כדלקמן: 1) אם רמות הכולסטרול שלך גבוהה אך אינך נושא גורמי סיכון נוספים להתפתחות מחלת לב (יתר לחץ דם, עישון, הסטוריה משפחתית למחלות אלה וכ׳) + 2) אם הינך נושא סיכון גבוה להתפתחות סוכרת (הסטוריה משפחתית וכ׳) , יש מקום לשקול בכובד ראש אם לטפל בך בסטטינים.

** בעקבות הפוסט פנו אלי מספר חולי סוכרת בשאלה: אני מטופל בסטטינים מה עלי לעשות? ובכן, הפוסט מתיחס לסיכון התפתחות מחלת הסוכרת ואינו רלבנטי לחולי סוכרת המטופלים בסטטינים !! אין עדות לכך שטיפול בסטטינים משבש את איזון הסוכרת. כיוון שכך,  אם אתם חולי סוכרת ומטופלים בסטטינים, המשיכו לקחת את הטיפול.

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